Open AccessIn Vitro Susceptibilities of Naegleria fowleri Strain HB-1 to Selected Antimicrobial Agents, Singly and in Combination
Author(s) -
Kenneth K. Lee,
Stephen L. Karr,
Ming M. Wong,
Paul D. Hoeprich
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.16.2.217
Subject(s) - amphotericin b , naegleria fowleri , minocycline , meningoencephalitis , antimicrobial , microbiology and biotechnology , tetracycline , in vitro , antibiotics , pharmacology , medicine , biology , virology , antifungal , biochemistry
The overall prognosis of primary amoebic meningoencephalitis remains poor. The results of this study support previous finding that amphotericin B is the most efficacious drug against theNaegleria species in in vitro testing. In addition, the methyl ester of amphotericin B, a new derivative, also appears to be an effective agent. Of the drug combinations studied, amphotericin B plus minocycline and amphotericin B plus tetracycline showed synergy. The clinical significance of these findings remains to be determined.