Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human | Zendy

D. Pappagianis | Zendy; Michael Collins | Zendy; Richard Hector | Zendy; J. Remington | Zendy

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Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human

Author(s) -

D. Pappagianis,

Michael Collins,

Richard Hector,

J. Remington

Publication year - 1979

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.16.2.123

Subject(s) - amphotericin b , microbiology and biotechnology , candida albicans , agar , yeast , fungemia , medicine , biology , antifungal , bacteria , biochemistry , genetics

Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 μg of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 μg/ml, respectively, for complete inhibition at 48 h.

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