Open AccessDevelopment of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human
Author(s) -
Demosthenes Pappagianis,
Michael Collins,
Richard F. Hector,
Jack S. Remington
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.16.2.123
Subject(s) - amphotericin b , microbiology and biotechnology , candida albicans , agar , yeast , biology , medicine , antifungal , bacteria , biochemistry , genetics
Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 μg of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 μg/ml, respectively, for complete inhibition at 48 h.