Morphological Changes of Escherichia coli Induced by Bicyclomycin | Zendy

Akira Someya | Zendy; Kenji Tanaka | Zendy; Nobuo Tanaka | Zendy

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Morphological Changes of Escherichia coli Induced by Bicyclomycin

Author(s) -

Akira Someya,

Kenji Tanaka,

Nobuo Tanaka

Publication year - 1979

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.16.1.87

Subject(s) - escherichia coli , cytoplasm , bleb (medicine) , bacterial outer membrane , lysis , vesicle , periplasmic space , lumen (anatomy) , cell membrane , biology , membrane , chemistry , microbiology and biotechnology , biophysics , biochemistry , gene , trabeculectomy , neuroscience , glaucoma

Electron microscopic studies with Escherichia coli revealed that bicyclomycin inhibits septum formation and converts the cells to filamentous forms. The antibiotic induced high undulation and numerous blebs of the outer membrane. Sometimes cytoplasmic contents leaked into the lumen of the bleb through a disrupted region of the membrane. Breakage of the outer membrane or blebs led to cell lysis. Electron-dense masses of amorphous material and vesicles were found in the cytoplasm.

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