Open AccessIsoniazid Inhibition of the Synthesis of Monounsaturated Long-Chain Fatty Acids in Mycobacterium tuberculosis H37Ra
Author(s) -
Leslie A. Davidson,
Kuni Takayama
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.16.1.104
Subject(s) - isoniazid , mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , antibiotics , medicine , pharmacology , chemistry , virology , biology , pathology
Isoniazid inhibited C24 and C26 monounsaturated fatty acid synthesis inMycobacterium tuberculosis H37Ra. Time courses of this inhibition and that of mycolic acid synthesis were similar.
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