Open AccessIn Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae
Author(s) -
Patrick R. Murray,
Judy L. Christman,
Gerald Medoff
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.15.3.452
Subject(s) - neisseria gonorrhoeae , cefoxitin , cefamandole , cephalosporin , microbiology and biotechnology , penicillin , tetracycline , antibiotics , in vitro , minimum inhibitory concentration , neisseriaceae , chemistry , biology , bacteria , biochemistry , staphylococcus aureus , genetics
The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.