In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae | Zendy

Patrick R. Murray | Zendy; Judy L. Christman | Zendy; Gerald Medoff | Zendy

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In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

Author(s) -

Patrick R. Murray,

Judy L. Christman,

Gerald Medoff

Publication year - 1979

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.15.3.452

Subject(s) - neisseria gonorrhoeae , cefoxitin , cefamandole , cephalosporin , microbiology and biotechnology , penicillin , tetracycline , antibiotics , in vitro , minimum inhibitory concentration , neisseriaceae , chemistry , biology , bacteria , biochemistry , staphylococcus aureus , genetics

The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.

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