Cefamandole Therapy in Anaerobic Infections | Zendy

Richard N. Greenberg | Zendy; Marcella Scalcini | Zendy; Charles V. Sanders | Zendy; A. Carter Lewis | Zendy

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Cefamandole Therapy in Anaerobic Infections

Author(s) -

Richard N. Greenberg,

Marcella Scalcini,

Charles V. Sanders,

A. Carter Lewis

Publication year - 1979

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.15.3.337

Subject(s) - cefamandole , bacteroides fragilis , medicine , neutropenia , anaerobic exercise , bacteroides , anaerobic bacteria , microbiology and biotechnology , gastroenterology , adverse effect , antibiotics , cephalosporin , surgery , biology , bacteria , chemotherapy , physiology , genetics

Thirty-one adult patients with infections due to anaerobic bacteria were treated with cefamandole. Bacteroides fragilis group (17) and Bacteroides melaninogenicus (13) were the most frequent anaerobes isolated. Duration of therapy varied from 2 to 49 days. Results were judged satisfactory in 26 cases, and unsatisfactory in 1 case. Four cases could not be evaluated. Adverse reactions occurred in 16 patients and included positive direct Coombs' test without hemolysis, transient liver function abnormalities, phlebitis, reversible neutropenia, fever, eosinophilia, and toxic epidermal necrolysis. The more significant reactions were associated with prolonged therapy. None was lethal. These data suggest that cefamandole is effective in treatment of most anaerobic infections.

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