Open AccessHR 756, a New Cephalosporin Active Against Gram-Positive and Gram-Negative Aerobic and Anaerobic Bacteria
Author(s) -
Harold C. Neu,
Nalinee Aswapokee,
P Aswapokee,
Kwung P. Fu
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.15.2.273
Subject(s) - microbiology and biotechnology , bacteroides fragilis , proteus mirabilis , cefoxitin , carbenicillin , enterobacter , klebsiella pneumoniae , pseudomonas aeruginosa , enterobacter cloacae , cephalosporin , staphylococcus aureus , enterobacteriaceae , shigella flexneri , ampicillin , escherichia coli , haemophilus influenzae , peptostreptococcus , biology , klebsiella , anaerobic bacteria , antibiotics , bacteria , biochemistry , genetics , gene
The in vitro activity of HR 756, 7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoximino)acetamido] cephalosporanic acid, was investigated against 659 isolates. HR 756 inhibitedNeisseria andHaemophilus species at concentrations similar to those needed with ampicillin. It inhibited β-lactamase-producingN. gonorrhoeae andH. influenzae . HR 756 was the most active compound tested against members of theEnterobacteriaceae , inhibiting most isolates ofEscherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella, Enterobacter , andShigella at concentrations of less than 0.1 μg/ml. It was twice as active as carbenicillin againstPseudomonas aeruginosa and inhibitedBacteroides fragilis as well as cefoxitin. HR 756 killedE. coli, Staphylococcus aureus , andP. aeruginosa at rates similar to other β-lactam antibiotics.