Open AccessIn Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae
Author(s) -
James W. Biddle,
Clyde Thornsberry
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.15.2.243
Subject(s) - josamycin , erythromycin , microbiology and biotechnology , neisseria gonorrhoeae , clindamycin , penicillin , agar dilution , antibiotics , biology , minimum inhibitory concentration
Randomly selected strains of β-lactamase-negative and β-lactamase-positiveNeisseria gonorrhoeae were tested by an agar dilution method for susceptibility to rosamicin, josamycin, erythromycin, clindamycin, and penicillin G. Rosamicin was more active than erythromycin, which was more active than josamycin or clindamycin; the latter two were similar in their activity. The susceptibility to the macrolide antibiotics and clindamycin was independent of β-lactamase production, but the penicillin minimal inhibitory concentrations were higher in the β-lactamase-positive group because of the enzyme.