Materno-Fetal Cephradine Transfer in Pregnancy | Zendy

Ian Craft | Zendy; Thomas C. Forster | Zendy

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Materno-Fetal Cephradine Transfer in Pregnancy

Author(s) -

Ian Craft,

Thomas C. Forster

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.6.924

Subject(s) - cephradine , pregnancy , medicine , abortion , obstetrics , fetus , antibiotics , gynecology , third trimester , cephalosporin , chemistry , biology , biochemistry , genetics

Cephradine, a semisynthetic cephalosporin, has widespread use. There is, however, a paucity of data on the transfer of this antibiotic in pregnancy. Studies were undertaken after an intravenous dose of 2 g of cephradine was given in two elective situations: (i) therapeutic abortion in the first trimester and (ii) elective cesarean section in late pregnancy. Blood and tissue levels of cephradine obtained showed that the antibiotic is rapidly transferred to the feto-placental unit throughout pregnancy after intravenous administration to the mother.

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