Open AccessIn Vitro and In Vivo Activity of a Synthetic Halogenated Quinoline Against Cryptococcus neoformans
Author(s) -
J. C. Hubbard,
Nancy K. Hall,
Howard W. Larsh
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.14.6.922
Subject(s) - cryptococcus neoformans , in vivo , quinoline , in vitro , microbiology and biotechnology , minimum inhibitory concentration , toxicity , biology , cryptococcus , strain (injury) , chemistry , biochemistry , organic chemistry , anatomy
The minimum inhibitory concentrations of a halogenated quinoline, 3-amino-7-chloro-3,4-dihydro-1-hydroxycarbostyril (CBS), against nine clinical strains ofCryptococcus neoformans were determined by in vitro testing. The CBS was fungistatic at a minimum concentration of 0.2 μg/ml at 48 h for several strains. In vivo toxicity studies were carried out in mice. Mice were also infected withC. neoformans strain Price and injected with various concentrations of CBS. Mean life expectancy of treated groups of animals was increased over infected untreated controls.