Comparative Evaluation of Piperacillin in Vitro | Zendy

Gordon M. Dickinson | Zendy; Timothy J. Cleary | Zendy; Thomas A. Hoffman | Zendy

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Comparative Evaluation of Piperacillin in Vitro

Author(s) -

Gordon M. Dickinson,

Timothy J. Cleary,

Thomas A. Hoffman

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.6.919

Subject(s) - piperacillin , ticarcillin , microbiology and biotechnology , carbenicillin , providencia , penicillin , ampicillin , antibiotics , enterobacter , cephalosporin , klebsiella pneumoniae , staphylococcus aureus , biology , pseudomonas aeruginosa , bacteria , antibiotic resistance , imipenem , escherichia coli , biochemistry , genetics , gene

The minimal inhibitory concentrations of piperacillin and seven other betalactam antibiotics were determined against 407 bacterial isolates. Piperacillin was found to be more active than ampicillin against susceptible gram-negative bacilli and more active than either carbenicillin or ticarcillin against Pseudomonas aeruginosa and streptococci. Although piperacillin was active against Klebsiella pneumoniae, this activity was less than that of the cephalosporins. Piperacillin was not active against penicillin-resistant Staphylococcus aureus and Enterobacteriaceae that were resistant to the other test antibiotics.

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