Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermum | Zendy

GengShuen Wu | Zendy; Thomas Nabih | Zendy; Leisa Youel | Zendy; W Peczyńska-Czoch | Zendy; John P. N. Rosazza | Zendy

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Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermum

Author(s) -

GengShuen Wu,

Thomas Nabih,

Leisa Youel,

W Peczyńska-Czoch,

John P. N. Rosazza

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.4.601

Subject(s) - vindoline , demethylation , fragmentation (computing) , chemistry , yield (engineering) , thin layer , chromatography , stereochemistry , organic chemistry , biology , biochemistry , vinblastine , materials science , layer (electronics) , ecology , gene expression , genetics , chemotherapy , gene , metallurgy , dna methylation

Vindoline (1a ) was transformed toO -demethylvindoline (1b ) bySepedonium chrysospermum ATCC 13378 in 33% yield. Thin-layer and high-pressure liquid chromatographic methods distinguished1b from previously reported microbial metabolites of vindoline. The structural proof of1b was based on its mass spectral fragmentation pattern and on its chemical and nuclear magnetic resonance spectral properties.

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