In Vitro Comparison of Kanamycin, Kanendomycin, Gentamicin, Amikacin, Sisomicin, and Dibekacin Against 200 Strains of Pseudomonas aeruginosa | Zendy

A. G. Paradelis | Zendy; J. Douboyas | Zendy; George Stathopoulos | Zendy; A. Grigoriadou-Edipides | Zendy; Costas Triantaphylidis | Zendy; J. Papapanagiotou | Zendy

Open Access

In Vitro Comparison of Kanamycin, Kanendomycin, Gentamicin, Amikacin, Sisomicin, and Dibekacin Against 200 Strains of Pseudomonas aeruginosa

Author(s) -

A. G. Paradelis,

J. Douboyas,

George Stathopoulos,

A. Grigoriadou-Edipides,

Costas Triantaphylidis,

J. Papapanagiotou

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.3.514

Subject(s) - sisomicin , amikacin , gentamicin , kanamycin , aminoglycoside , microbiology and biotechnology , pseudomonas aeruginosa , antibiotics , minimum inhibitory concentration , chemistry , tobramycin , biology , bacteria , genetics

The antimicrobial activity of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa was compared. Dibekacin was found to be the most active against the tested organisms, whereas the other aminoglycoside antibiotics fell in the following order of diminishing antibacterial potency: amikacin, sisomicin, gentamicin, kanendomycin, and kanamycin. Seven strains showed high-level resistance to gentamicin (minimal inhibitory concentration, 400 mug/ml), and two of them were also resistant to amikacin and sisomicin (minimal inhibitory concentration, 75 mug/ml). The minimal inhibitory concentration of dibekacin for these seven strains was 0.625 mug/ml.

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