Open AccessPenetration of Clindamycin into Decubitus Ulcers
Author(s) -
Stephen A. Berger,
Michael Barza,
Jane N. Haher,
J McFarland,
Samuel Louie,
Anne Kane
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.14.3.498
Subject(s) - clindamycin , medicine , penetration (warfare) , antibiotics , surgery , anesthesia , microbiology and biotechnology , biology , operations research , engineering
Forty tissue samples, primarily of skin and bone, were obtained from 29 patients undergoing excision of decubitus ulcers after intravenous injection of 600 mg of clindamycin. Antibiotic concentrations exceeded 2.5 μg/g in 80% of the samples. In 50% of the instances, tissue levels were greater than those simultaneously present in the serum.