Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function | Zendy

Gary A. Roselle | Zendy; Carol A. Kauffman | Zendy

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Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Author(s) -

Gary A. Roselle,

Carol A. Kauffman

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.3.398

Subject(s) - amphotericin b , lymphocyte , concanavalin a , in vitro , immunology , pharmacology , flucytosine , biology , medicine , microbiology and biotechnology , biochemistry , antifungal

The effects of amphotericin B, 5-fluorocytosine, and the combination of both drugs on lymphocyte function in vitro were investigated. Amphotericin B, alone or in combination with 5-fluorocytosine, significantly suppressed both spontaneous lymphocyte transformation and the response of lymphocytes to stimulation with streptokinase-streptodornase. 5-Fluorocytosine had no effect on spontaneous or antigen-induced transformation. Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A were not changed by exposure to amphotericin B, 5-fluorocytosine, or the combination of both drugs. T-lymphocyte receptors for sheep erythrocytes and B-lymphocyte surface immunoglobulin and receptors for complement were not changed by treatment with amphotericin B or 5-fluorocytosine.

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