Open AccessPharmacokinetics of Cefamandole in Infants and Children
Author(s) -
Stuart H. Walker,
Victoria P. Gahol
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.14.3.315
Subject(s) - cefamandole , pharmacokinetics , dosing , medicine , minimum inhibitory concentration , serum concentration , pediatrics , cephalosporin , physiology , anesthesia , pharmacology , antibiotics , chemistry , biochemistry
In infants less than 3 months of age, the serum concentration of cefamandole during therapy was higher and more prolonged than that in children older than 1 year. A dosage of 37 mg/kg administered intravenously at 6-h intervals provided a serum concentration in excess of the minimum inhibitory concentrations of common bacterial pathogens for 4 h, and in young infants for 5 h, after dosing.