Erythropoietin Concentration in Amphotericin B-Induced Anemia | Zendy

Rob Roy MacGregor | Zendy; John E. Bennett | Zendy; Allan J. Erslev | Zendy

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Erythropoietin Concentration in Amphotericin B-Induced Anemia

Author(s) -

Rob Roy MacGregor,

John E. Bennett,

Allan J. Erslev

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.2.270

Subject(s) - erythropoietin , amphotericin b , hematocrit , anemia , medicine , urine , bone marrow , gastroenterology , pharmacology , dermatology , antifungal

Amphotericin B was given to six patients with systemic fungal infections. A dose averaging 1.78 g, administered from 42 to 144 days, was associated with a fall in hematocrit to a mean value of 25.8%. Despite this degree of anemia, no elevation of erythropoietin concentrations in urine or serum could be detected. Thus, amphotericin appears to cause anemia by inhibiting erythropoietin production rather than by suppressing bone marrow activity directly.

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