Pharmacokinetics of Gentamicin Administered Intratracheally to Rats | Zendy

T. Trnovec | Zendy; Javarová | Zendy; M. Kettner | Zendy; M. Gregušková | Zendy; S Bezek | Zendy; A Gajdošík | Zendy; Alena Kyselova | Zendy

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Pharmacokinetics of Gentamicin Administered Intratracheally to Rats

Author(s) -

T. Trnovec,

Javarová,

M. Kettner,

M. Gregušková,

S Bezek,

A Gajdošík,

Alena Kyselova

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.2.165

Subject(s) - gentamicin , pharmacokinetics , urine , pharmacology , absorption (acoustics) , gentamicin sulfate , chemistry , antibiotics , medicine , biochemistry , physics , acoustics

The pharmacokinetics of intratracheally instilled and intravenously injected gentamicin were compared in the rat and analyzed by a one-compartment open model. The maximum concentration of gentamicin in plasma occurred within 10 min after intratracheal instillation. Considerable amounts of gentamicin were absorbed from lungs after intratracheal instillation, as shown by its concentrations in plasma and elimination in urine. The data suggest that the absorption of gentamicin from the pulmonary system would be sufficient to maintain therapeutic levels of this agent in plasma.

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