Antibiotic Biosynthesis by Cofermentation of Blocked Mutants of Two Micromonospora Species | Zendy

B. K. Lee | Zendy; T. L. NAGABHUSHAN | Zendy; R. G. Condon | Zendy; Alexei Cooper | Zendy; J. Allan Waitz | Zendy

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Antibiotic Biosynthesis by Cofermentation of Blocked Mutants of Two Micromonospora Species

Author(s) -

B. K. Lee,

T. L. NAGABHUSHAN,

R. G. Condon,

Alexei Cooper,

J. Allan Waitz

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.14.1.73

Subject(s) - micromonospora , aminocyclitol , antibiotics , mutant , biosynthesis , aminoglycoside , microbiology and biotechnology , biology , biochemistry , stereochemistry , chemistry , bacteria , genetics , gene , streptomyces

Two aminocyclitol-negativeMicromonospora mutants representing two different species,M. purpurea andM. inyoensis , and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when 2-deoxystreptamine was added. When combined they produced gentamicins A, X2 , C1a , and C2b , which all have an amino group at the 2′ position, and gentamicin B, which has a hydroxyl group at this position instead.

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