Dissociation Between Ion Permeability and the Lethal Action of Polyene Antibiotics on Candida albicans | Zendy

Winston C. Chen | Zendy; Dong-Lang Chou | Zendy; David S. Feingold | Zendy

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Dissociation Between Ion Permeability and the Lethal Action of Polyene Antibiotics on Candida albicans

Author(s) -

Winston C. Chen,

Dong-Lang Chou,

David S. Feingold

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.13.6.914

Subject(s) - polyene , nystatin , candida albicans , amphotericin b , antibiotics , chemistry , potassium , microbiology and biotechnology , hydrochloride , aspergillus fumigatus , biochemistry , pharmacology , biology , antifungal , organic chemistry

Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs.

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