Open AccessCerebrospinal Fluid Penetration of Amikacin
Author(s) -
Dalius J. Briedis,
Hugh G. Robson
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.13.6.1042
Subject(s) - cerebrospinal fluid , amikacin , penetration (warfare) , intramuscular injection , medicine , lumbar puncture , anesthesia , antibiotics , microbiology and biotechnology , biology , operations research , engineering
Adult volunteers underwent a single lumbar puncture 1 to 8.5 h after one 7.5-mg/kg intramuscular amikacin injection. Eighteen showed no detectable drug in cerebrospinal fluid; six had concentrations <0.5 mug/ml.