Open AccessFungal Toxicity of Phosfon D and Its Reversion by Lipids
Author(s) -
G. L. Vannini,
G. Dall'Olio,
A. Donini
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.13.4.699
Subject(s) - dermatophyte , reversion , ergosterol , microsporum , toxicity , microbiology and biotechnology , oleic acid , fungal growth , biology , biochemistry , chemistry , trichophyton , antifungal , organic chemistry , gene , phenotype
The growth retardant Phosfon D inhibits the growth of some yeasts and human pathogenic filamentous fungi. The toxic effects of the compound on the dermatophyteMicrosporum cookei were completely reversed by adding ergosterol and oleic acid to the medium. The significance of these findings is discussed.