Open AccessMode of action of the Haemophilus bactericidal factor
Author(s) -
R. G. Streker,
Richard A. Venezia,
Richard G. Robertson
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.13.3.527
Subject(s) - haemophilus influenzae , escherichia coli , dna , dna synthesis , haemophilus , microbiology and biotechnology , bacteriocin , mode of action , pasteurellaceae , protein biosynthesis , biology , biochemistry , chemistry , antibiotics , bacteria , genetics , gene , antimicrobial
Haemocin, a bacteriocin produced by Haemophilus influenzae b, caused pronounced cell elongation of the sensitive strains H. influenzae Rd and Escherichia coli CR34 thyA. In the sensitive strains, haemocin markedly inhibited the synthesis of deoxyribonucleic acid (DNA) but did not affect either ribonucleic acid or protein synthesis. The observed inhibition in synthesis of DNA was not due to degradation of preexisting DNA. The data suggest that haemocin may specifically inhibit DNA synthesis.