Open AccessSynergistic Action of Amphotericin B and Antioxidants Against Certain Opportunistic Yeast Pathogens
Author(s) -
William H. Beggs,
Fred A. Andrews,
George A. Sarosi
Publication year - 1978
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.13.2.266
Subject(s) - butylated hydroxyanisole , candida albicans , nordihydroguaiaretic acid , microbiology and biotechnology , corpus albicans , amphotericin b , yeast , fungicide , propyl gallate , chemistry , biology , antimicrobial , antifungal , biochemistry , antioxidant , enzyme , lipoxygenase , botany
Results of earlier turbidimetric growth experiments showed that certain antioxidants prolonged the antifungal activity of amphotericin B (AB) againstCandida albicans , presumably by retarding autoxidative destruction of the drug. Viability studies were designed to examine this in more detail. Subinhibitory concentrations of either butylated hydroxyanisole,n -propyl gallate, or nordihydroguaiaretic acid in combination with fungistatic levels of AB exerted synergistic fungicidal activity against two strains ofC. albicans and one ofC. parapsilosis . Although synergism was not seen in tests with a strain ofTorulopsis glabrata , antioxidants prolonged the inhibitory action of AB against this organism. On the basis of these findings and other considerations that are discussed, it is suggested that stabilization of AB and the ability to act synergistically with AB represent two distinctly different effects of the antioxidants.