Outbreak of Multiply Drug-Resistant Proteus mirabilis Originating in a Surgical Intensive Care Unit: In Vitro Susceptibility Pattern | Zendy

Thomas T. Yoshikawa | Zendy; Sharon A. Shibata | Zendy; Anthony W. Chow | Zendy; Lucien B. Guze | Zendy

Open Access

Outbreak of Multiply Drug-Resistant Proteus mirabilis Originating in a Surgical Intensive Care Unit: In Vitro Susceptibility Pattern

Author(s) -

Thomas T. Yoshikawa,

Sharon A. Shibata,

Anthony W. Chow,

Lucien B. Guze

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.13.2.177

Subject(s) - netilmicin , proteus mirabilis , amikacin , sisomicin , microbiology and biotechnology , gentamicin , tobramycin , trimethoprim , antibiotics , drug resistance , biology , medicine , staphylococcus aureus , bacteria , genetics

A multiply drug-resistant strain ofProteus mirabilis was isolated from 14 patients on a surgical service. Antimicrobial susceptibility studies demonstrated that the organism was highly resistant to numerous antibiotics, including gentamicin, tobramycin, and sisomicin. The organism was susceptible in vitro to amikacin but had low-level resistance to netilmicin. In vitro susceptibility studies with combinations of cephalothin with netilmicin and trimethoprim with sulfamethoxazole showed these drugs to be synergistic. Other drug combinations failed to act synergistically.

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