Reversible Inhibition of Cellular Metabolism by Ribavirin | Zendy

Alf Larsson | Zendy; K Stenberg | Zendy; Bo Öberg | Zendy

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Reversible Inhibition of Cellular Metabolism by Ribavirin

Author(s) -

Alf Larsson,

K Stenberg,

Bo Öberg

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.13.2.154

Subject(s) - ribavirin , metabolism , dna synthesis , cell division , chemistry , drug , cell , biochemistry , rna , protein biosynthesis , broad spectrum , dna , pharmacology , biology , combinatorial chemistry , genotype , gene

The broad spectrum antiviral drug ribavirin (Virazole, 1-β-d -ribofuranosyl-1,2,4-triazole-3-carboxamide) inhibits cellular macromolecular synthesis as well as cell division in eucaryotic cells. The concentration and time dependence have been studied. One-hour treatment with 25 μM ribavirin or 18 h with 2 μM inhibited the deoxyribonucleic acid synthesis to 50%. Higher concentrations of ribavirin were required to obtain a similar inhibition of ribonucleic acid and protein synthesis. This effect on cell metabolism and cell division can be reversed by removing the drug from the cells.

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