Hemodialysis-Associated Infections: Treatment with Cephapirin | Zendy

Steven Berman | Zendy; W H Boughton | Zendy; Jared G. Sugihara | Zendy; E. G. C. Wong | Zendy; Arnold W. Siemsen | Zendy

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Hemodialysis-Associated Infections: Treatment with Cephapirin

Author(s) -

Steven Berman,

W H Boughton,

Jared G. Sugihara,

E. G. C. Wong,

Arnold W. Siemsen

Publication year - 1978

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.13.1.4

Subject(s) - hemodialysis , medicine , toxicity , antimicrobial , antibiotics , pharmacology , biology , microbiology and biotechnology

Large doses of cephapirin (50 mg/kg) administered during the first and last half hours of routine hemodialysis produced effective antimicrobial serum concentrations for 48 h. Repetitive administration during five successive hemodialysis sessions did not result in accumulation or accelerated metabolism of cephapirin. Ten infectious episodes in nine patients were treated in this manner with good clinical results and no toxicity.

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