Radiometric Determination of the Concentration of Amphotericin B in Body Fluids | Zendy

Roy L. Hopfer | Zendy; D Gröschel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Radiometric Determination of the Concentration of Amphotericin B in Body Fluids

Author(s) -

Roy L. Hopfer,

D Gröschel

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.12.6.733

Subject(s) - amphotericin b , candida albicans , paecilomyces , microbiology and biotechnology , agar , chemistry , antibiotics , incubation , biology , antifungal , biochemistry , bacteria , botany , genetics

A new assay was developed to determine the concentration of amphotericin B in body fluids. The Bactec radiometric system was used to measure CO2 production by a test strain,Candida albicans MDA 448, in the presence of amphotericin B. After 5-h incubation, drug concentrations as low as 0.2 μg/ml could be detected. The results are comparable to those of the commonly used agar diffusion assay withPaecilomyces varioti .

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research