Open AccessIn Vitro Activities of Five Oral Cephalosporins Against Aerobic Pathogenic Bacteria
Author(s) -
Smith Shadomy,
Gerald E. Wagner,
M Carver
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.12.5.609
Subject(s) - cefaclor , cephalosporin , cephradine , enterobacter cloacae , microbiology and biotechnology , proteus vulgaris , proteus mirabilis , enterobacter , enterobacter aerogenes , biology , agar dilution , klebsiella pneumoniae , minimum inhibitory concentration , antibiotics , escherichia coli , bacteria , antibacterial activity , staphylococcus aureus , biochemistry , genetics , gene
Cefaclor (Lilly 99638) and cefatrizine (BL-S640, SK&F 70771) are orally absorbed, broad-spectrum semisynthetic cephalosporins. They were compared in vitro with cephalexin, cephaloglycin, and cepharadine against a variety of aerobic pathogenic bacteria by an agar dilution procedure. Cefaclor and cefatrizine were found to be similar or superior to cephalexin, cephaloglycin, and cephradine in terms of activity against gram-positive cocci other than enterococci. Only cefatrizine demonstrated any potentially useful activity against some susceptible isolates of enterococci. Cefaclor and cefatrizine also were highly active, equally or more so than the other oral cephalosporins, against several gram-negative species including Escherichia coli, Enterobacter aerogenes, and Klebsiella pneumoniae. None of the cephalosporins were particularly active against Enterobacter cloacae. Both cefaclor and cefatrizine were active against Proteus mirabilis; cefatrizine was uniquely active against indolepositive Proteus species.
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