Open AccessCyclic Thymineless Death Significantly Increases Frequency of R-Plasmid Elimination
Author(s) -
M J Tribe,
R. J. Pinney
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.12.4.555
Subject(s) - plasmid , escherichia coli , strain (injury) , microbiology and biotechnology , thymine , biology , chemistry , genetics , dna , gene , anatomy
Thymine starvation of Escherichia coli strain C600 thy (R46) eliminated the R plasmid at a frequency of 17%. This was increased fourfold, to 68%, after the same culture was subjected to an additional three cycles of growth followed by thymineless death.
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