Factors Involved in Beta-Lactam Antibiotic Resistance in Pseudomonas aeruginosa | Zendy

Hitoshi Ohmori | Zendy; Akiko Azuma | Zendy; Yoji Suzuki | Zendy; Yoshinobu Hashimoto | Zendy

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Factors Involved in Beta-Lactam Antibiotic Resistance in Pseudomonas aeruginosa

Author(s) -

Hitoshi Ohmori,

Akiko Azuma,

Yoji Suzuki,

Yoshinobu Hashimoto

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.12.4.537

Subject(s) - pseudomonas aeruginosa , antibiotics , microbiology and biotechnology , lactam , mutant , beta lactam , pseudomonadales , antibiotic resistance , biology , bacteria , chemistry , genetics , stereochemistry , gene

A temperature-sensitive mutant, strain SS, which is assumed to be devoid of beta-lactamase activity and deficient in a permeability barrier to antibiotics, was isolated from a beta-lactamase-less mutant, strain L-2, derived from Pseudomonas aeruginosa IFO 3080. By comparing the beta-lactam antibiotic susceptibility between strains IFO 3080, L-2, and SS, the involvement of both beta-lactamase and a permeability barrier in determining the beta-lactam antibiotic resistance was estimated.

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