Open AccessIn Vitro Activity of Cefaclor, a New Orally Administered Cephalosporin Antibiotic
Author(s) -
Jerome Santoro,
Matthew E. Levison
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.12.3.442
Subject(s) - cefaclor , cephalosporin , proteus mirabilis , staphylococcus aureus , microbiology and biotechnology , klebsiella pneumoniae , antimicrobial , antibiotics , antibacterial agent , enterobacteriaceae , cephalosporin antibiotic , antibacterial activity , chemistry , escherichia coli , biology , bacteria , biochemistry , genetics , gene
The in vitro antibacterial activity of cefaclor, cephalothin, and cephalexin against 261 clinical isolates ofStaphylococcus aureus andEnterobacteriaceae was compared. Cefaclor and cephalexin were about equally active againstS. aureus . Cefaclor was the most active cephalosporin againstEscherichia coli, Proteus mirabilis , andKlebsiella pneumoniae . The effect on the antimicrobial activity using a relatively high and low inoculum was pronounced for cefaclor when compared with that of cephalothin.