Enhancement of Antistaphylococcal Activity of Nafcillin and Oxacillin by Sisomicin and Netilmicin | Zendy

Chatrchai Watanakunakorn | Zendy; Cheryl Glotzbecker | Zendy

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Enhancement of Antistaphylococcal Activity of Nafcillin and Oxacillin by Sisomicin and Netilmicin

Author(s) -

Chatrchai Watanakunakorn,

Cheryl Glotzbecker

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.12.3.346

Subject(s) - sisomicin , netilmicin , nafcillin , staphylococcus aureus , microbiology and biotechnology , antibiotics , meticillin , medicine , chemistry , micrococcaceae , antibacterial agent , biology , gentamicin , penicillin , bacteria , tobramycin , genetics

The in vitro activity of sisomicin, netilmicin, nafcillin, and oxacillin against 35 strains of Staphylococcus aureus isolated from blood cultures of patients with endocarditis or septicemia was studied. The effects of combinations of either of the two newer aminoglycosides and either of the two penicillinase-resistant penicillins on the killing of S. aureus were investigated. All S. aureus strains were susceptible to the four antibiotics. Enhancement of antistaphylococcal activity was demonstrated by the antibiotic combinations.

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