Biotransformation of Sisomicin to Gentamicin C 2b | Zendy

B. K. Lee | Zendy; Janet V. Bailey | Zendy; R. G. Condon | Zendy; JOSEPH A. MARQUEZ | Zendy; Gerald H. Wagman | Zendy; Marvin Weinstein | Zendy

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Biotransformation of Sisomicin to Gentamicin C 2b

Author(s) -

B. K. Lee,

Janet V. Bailey,

R. G. Condon,

JOSEPH A. MARQUEZ,

Gerald H. Wagman,

Marvin Weinstein

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.12.3.335

Subject(s) - sisomicin , biotransformation , gentamicin , micromonospora , chemistry , methylation , microbiology and biotechnology , pharmacology , antibiotics , biology , biochemistry , bacteria , enzyme , genetics , streptomyces , tobramycin , gene

Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6'-N-methylation and the (4'-5')-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.

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