Open AccessBactericidal Activity of the Combinations of Gentamicin with Clindamycin or Chloramphenicol Against Species of Escherichia coli and Bacteroides fragilis
Author(s) -
Jean Klášterský,
M. Husson
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.12.2.135
Subject(s) - bacteroides fragilis , gentamicin , clindamycin , chloramphenicol , microbiology and biotechnology , escherichia coli , bacteroides , antibiotics , biology , chemistry , bacteria , biochemistry , genetics , gene
The bactericidal activity of clindamycin, chloramphenicol, and gentamicin alone and of gentamicin plus clindamycin and gentamicin plus chloramphenicol was studied on 8 strains ofEscherichia coli and 10 strains ofBacteroides fragilis isolated from clinical material. Gentamicin did not interfere with the activity of clindamycin or chloramphenicol againstB. fragilis . The activity of gentamicin againstE. coli was not influenced by clindamycin, but chloramphenicol suppressed the rapid bactericidal activity of gentamicin in seven out of eight strains ofE. coli examined.