Open AccessDistribution of Amikacin in Serum, Muscle, and Fat in Children After a Single Intramuscular Injection
Author(s) -
Franz Daschner,
Eva Reiß,
J. Engert
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.11.6.1081
Subject(s) - amikacin , intramuscular injection , intramuscular fat , endocrinology , serum concentration , medicine , body weight , muscle tissue , chemistry , biology , zoology , antibiotics , biochemistry
Amikacin concentrations in serum, muscle, and fat were determined in 41 children after intramuscular administration of 7.5 mg/kg of body weight. At 1.5 h amikacin reached peak concentrations in serum (mean value, 14.9 μg/ml) as well as in muscle (2.2 μg/g) and fat (1.89 μg/g) tissue; from then on all concentrations declined. Amikacin concentrations exceeded 1 μg/g in muscle for at least 3 h and in fat for at least 4 h.