Distribution of Amikacin in Serum, Muscle, and Fat in Children After a Single Intramuscular Injection | Zendy

Franz Daschner | Zendy; Eva Reiß | Zendy; J. Engert | Zendy

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Distribution of Amikacin in Serum, Muscle, and Fat in Children After a Single Intramuscular Injection

Author(s) -

Franz Daschner,

Eva Reiß,

J. Engert

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.11.6.1081

Subject(s) - amikacin , intramuscular injection , intramuscular fat , endocrinology , serum concentration , medicine , body weight , muscle tissue , chemistry , biology , zoology , antibiotics , biochemistry

Amikacin concentrations in serum, muscle, and fat were determined in 41 children after intramuscular administration of 7.5 mg/kg of body weight. At 1.5 h amikacin reached peak concentrations in serum (mean value, 14.9 μg/ml) as well as in muscle (2.2 μg/g) and fat (1.89 μg/g) tissue; from then on all concentrations declined. Amikacin concentrations exceeded 1 μg/g in muscle for at least 3 h and in fat for at least 4 h.

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