Open AccessGas Chromatographic Determination of 5-Fluorocytosine: a Modified Extraction Method
Author(s) -
Siok-Hui Wee,
John P. Anhalt
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.11.5.914
Subject(s) - chromatography , extraction (chemistry) , gas chromatography , chemistry , correlation coefficient , mathematics , statistics
A modified procedure for the gas-chromatographic determination of 5-fluorocytosine in serum is described. A more volatile solvent mixture for extraction is used to reduce sample preparation time before chromatography. Comparison of values from assay of 12 serum samples by our method and the reference method gave a correlation coefficient of 0.99.