Open AccessSusceptibility of Clinical Isolates of Cytomegalovirus to Human Interferon
Author(s) -
Boško Postic,
John Dowling
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.11.4.656
Subject(s) - vesicular stomatitis virus , virology , cytomegalovirus , interferon , biology , human cytomegalovirus , vesicular stomatitis indiana virus , virus , strain (injury) , in vitro , microbiology and biotechnology , foscarnet , betaherpesvirinae , stomatitis , herpesviridae , viral disease , medicine , ganciclovir , genetics , anatomy , dermatology
Human cell culture-derived interferon was shown to inhibit human cytomegalovirus in vitro. A prototype strain, Davis, and six clinical isolates of cytomegalovirus were tested. All six isolates showed uniform susceptibility to interferon, exceeding that of the Davis strain by two- to fourfold. The latter virus was found to be 32 to 4 times less susceptible than the sensitive indicator, vesicular stomatitis virus. However, the laboratory finding of susceptibility to an antiviral material may not relate to its clinical effectiveness.