Open AccessMicrobial Formation of 4-Thiouracil
Author(s) -
Lester A. Dolak,
W. T. Sokolski,
S. A. Mizsak,
D.W. Stroman,
Oldrich K. Sebek
Publication year - 1977
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.11.3.569
Subject(s) - thiouracil , yield (engineering) , antibacterial activity , chemistry , streptomyces , nuclear magnetic resonance spectroscopy , microbiology and biotechnology , biology , bacteria , stereochemistry , materials science , genetics , thyroid , metallurgy
A soil organism identified asStreptomyces libani var.soldani was found to produce 4-thiouracil. The product was isolated in a yield of 150 μg/ml of filtered beer and characterized by C-13 magnetic resonance and high-resolution mass spectroscopy. The product has a broad antibacterial spectrum but low specific activity.