Microbial Formation of 4-Thiouracil | Zendy

Lester A. Dolak | Zendy; W. T. Sokolski | Zendy; S. A. MIZSAK | Zendy; D.W. Stroman | Zendy; Oldrich K. Sebek | Zendy

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Microbial Formation of 4-Thiouracil

Author(s) -

Lester A. Dolak,

W. T. Sokolski,

S. A. MIZSAK,

D.W. Stroman,

Oldrich K. Sebek

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.11.3.569

Subject(s) - thiouracil , yield (engineering) , antibacterial activity , chemistry , streptomyces , nuclear magnetic resonance spectroscopy , microbiology and biotechnology , biology , bacteria , stereochemistry , materials science , genetics , thyroid , metallurgy

A soil organism identified asStreptomyces libani var.soldani was found to produce 4-thiouracil. The product was isolated in a yield of 150 μg/ml of filtered beer and characterized by C-13 magnetic resonance and high-resolution mass spectroscopy. The product has a broad antibacterial spectrum but low specific activity.

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