Comparison of the Actions of 5-Fluorouracil and Ftorafur in Escherichia coli | Zendy

Priscilla P. Saunders | Zendy; LianYu Chao | Zendy

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Comparison of the Actions of 5-Fluorouracil and Ftorafur in Escherichia coli

Author(s) -

Priscilla P. Saunders,

LianYu Chao

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.11.3.451

Subject(s) - fluorouracil , escherichia coli , uracil , chemistry , biology , biochemistry , chemotherapy , dna , gene , genetics

The actions of 5-fluorouracil (FU) and Ftorafur (NCS 148958) were compared in Escherichia coli B3 to determine if Ftorafur can act in ways other than through the production of FU. Very high concentrations of Ftorafur relative to FU were necessary to achieve a comparable inhibition of cell growth. Inhibition by both agents could be reversed by uracil. An FU-resistant strain and an Ftorafur-resistant strain were isolated and found to be cross-resistant to Ftorafur and FU, respectively.

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