Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy | Zendy

Niels FrimodtMøller | Zendy; A. Leth Bak | Zendy; A Stenderup | Zendy; H Zachariae | Zendy; H Afzelius | Zendy

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Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

Author(s) -

Niels FrimodtMøller,

A. Leth Bak,

A Stenderup,

H Zachariae,

H Afzelius

Publication year - 1977

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.11.3.388

Subject(s) - tetracycline , drug resistance , plasmid , escherichia coli , microbiology and biotechnology , bacteria , drug , antibiotics , medicine , acne , pharmacotherapy , biology , pharmacology , dermatology , dna , biochemistry , genetics , gene

The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease (acne vulgaris) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.

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