Open AccessComparative In Vitro Studies of Cinoxacin, Nalidixic Acid, and Oxolinic Acid
Author(s) -
Ralph C. Gordon,
Lynne Stevens,
Charles E. Edmiston,
Kanwal Mohan
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.6.918
Subject(s) - nalidixic acid , oxolinic acid , agar dilution , minimum inhibitory concentration , agar , microbiology and biotechnology , antibacterial agent , biology , in vitro , chemistry , biochemistry , bacteria , antibiotics , antibiotic resistance , genetics
Cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138Shigella isolates and somewhat less active than oxolinic acid on a weight basis. Cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in Mueller-Hinton agar. Plate dilution studies of the effect of changes in agar pH on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing pH. Protein binding investigations revealed a high degree of binding, with nalidixic acid > oxolinic acid > cinoxacin.