Open AccessConcentration of Cefamandole in Serum Interstitial Fluid, Bile, and Urine
Author(s) -
N. Waterman,
H.-U. Eickenberg,
L. Scharfenberger
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.4.733
Subject(s) - cefamandole , interstitial fluid , urine , antibiotics , cefalotin , chemistry , cephalosporin , bacteria , microbiology and biotechnology , diffusion , body fluid , medicine , biology , biochemistry , genetics , thermodynamics , physics
Cefamandole readily diffuses from the serum into soft tissue interstitial fluid. The rate of diffusion differs little from that of cephalothin. The concentrations of antibiotic were greater in bile and urine during the entire period of study than is necessary to kill susceptible pathogenic bacteria present in these fluids.