Open AccessAntiviral Effects of Virazole in Chronic Hepatitis B Surface Antigen-Seropositive Chimpanzees
Author(s) -
Alexander E. Denes,
James W. Ebert,
Kenneth R. Berquist,
Brittany L. Murphy,
James E. Maynard
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.3.571
Subject(s) - ribavirin , virology , antigen , medicine , hepatitis b , immunology , chronic hepatitis , adverse effect , virus
Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HBs Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.