Antiviral Effects of Virazole in Chronic Hepatitis B Surface Antigen-Seropositive Chimpanzees | Zendy

Alexander E. Denes | Zendy; James W. Ebert | Zendy; Kenneth R. Berquist | Zendy; Bert L. Murphy | Zendy; James E. Maynard | Zendy

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Antiviral Effects of Virazole in Chronic Hepatitis B Surface Antigen-Seropositive Chimpanzees

Author(s) -

Alexander E. Denes,

James W. Ebert,

Kenneth R. Berquist,

Bert L. Murphy,

James E. Maynard

Publication year - 1976

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.10.3.571

Subject(s) - ribavirin , virology , antigen , medicine , hepatitis b , immunology , chronic hepatitis , adverse effect , virus

Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HBs Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.

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