Open AccessEffect of Renal Failure and Dialysis on the Serum Concentration of the Aminoglycoside Amikacin
Author(s) -
T. Madhavan,
Kathy Yaremchuk,
Nathan W. Levin,
Donald J. Pohlod,
Keith H. Burch,
Evelyn Fisher,
Felicia Cox,
Edward Quinn
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.3.464
Subject(s) - amikacin , medicine , hemodialysis , peritoneal dialysis , aminoglycoside , dialysis , antibiotics , urology , gastroenterology , surgery , microbiology and biotechnology , biology
Serum and dialysate levels of amikacin were determined at appropriate intervals after a 300-mg intravenous dose as a continuous infusion in six patients with end-stage renal failure undergoing hemodialysis and in three patients on peritoneal dialysis. The mean serum half-life of amikacin was 3.75 h during (or after) hemodialysis and 29 h during (or after) peritoneal dialysis. Although not on hemodialysis in the same six patients, the serum half-life was 28 h. The results indicate that the maintenance dose of amikacin should be markedly decreased in patients with severe renal failure even if they are treated with peritoneal dialysis, and that serial serum antibiotic concentrations are essential to prevent cumulative toxicity of the drug.