Open AccessComparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans
Author(s) -
Bernard E. Cabana,
Donald R. Van Harken,
G. H. Hottendorf
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.2.307
Subject(s) - pharmacokinetics , cephalosporin , pharmacology , urine , metabolism , drug metabolism , antibiotics , cephalosporin antibiotic , excretion , biology , chemistry , drug , microbiology and biotechnology , biochemistry
Comparative drug disposition studies in mice, rats, dogs, and humans indicate that cephapirin, a new semisynthetic cephalosporin antibiotic that exhibits broad-spectrum antimicrobial activity, is metabolized to desacetylcephapirin in these species. Pharmacokinetic analyses of the concentrations of cephapirin and desacetylcephapirin in plasma and urine reveal that the rate and extent of deacetylation decreases from rodents to dogs to humans. The kinetic analyses also suggest that the kidney performs a role not only in the excretion but also in the metabolism of cephapirin to desacetylcephapirin.