Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans | Zendy

Elisabeth S. Rattie | Zendy; Peter D. Bernardo | Zendy; Louis J. Ravin | Zendy

Open Access

Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans

Author(s) -

Elisabeth S. Rattie,

Peter D. Bernardo,

Louis J. Ravin

Publication year - 1976

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.10.2.283

Subject(s) - cephradine , pharmacokinetics , bioavailability , pharmacology , absorption (acoustics) , medicine , antibiotics , chemistry , cephalosporin , biochemistry , physics , acoustics

Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms.

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