Open AccessPharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans
Author(s) -
Elisabeth S. Rattie,
Peter D. Bernardo,
Louis J. Ravin
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.10.2.283
Subject(s) - cephradine , pharmacokinetics , bioavailability , pharmacology , absorption (acoustics) , medicine , antibiotics , chemistry , cephalosporin , biochemistry , physics , acoustics
Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms.