Antibacterial Activity of Lividomycin Toward R Factor-Resistant Strains of Escherichia coli | Zendy

Masahito Yamaguchi | Zendy; Fujio Kobayashi | Zendy; Susumu Mitsuhashi | Zendy

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Antibacterial Activity of Lividomycin Toward R Factor-Resistant Strains of Escherichia coli

Author(s) -

Masahito Yamaguchi,

Fujio Kobayashi,

Susumu Mitsuhashi

Publication year - 1972

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.1.2.139

Subject(s) - escherichia coli , kanamycin , microbiology and biotechnology , alkaline phosphatase , streptomycin , biology , enterobacteriaceae , antibiotics , chemistry , biochemistry , enzyme , gene

Forty-eight R factors conferring resistance to both kanamycin (KM) and streptomycin (SM) were demonstrated from 1,270Escherichia coli strains of clinical origin. Among these R factors isolated, 42 also conferred resistance to the new antibiotic lividomycin (LV). Extracts ofE. coli ML1410 carrying one such factor (RM81 ) inactivated LV as well as KM and SM. But extracts ofE. coli ML1410 carrying an R factor (RM82 or RM83 ) sensitive to LV could not inactivate LV. LV inactivation required both adenosinetriphosphate (ATP) and Mg2+ . Inactivated LV was reactivable by alkaline phosphatase. Isotopic studies with labeled ATP and elemental analysis of the reaction product indicate that it is a monophosphorylated derivative of LV.

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