Activity of Lividomycin Against Pseudomonas aeruginosa: Its Inactivation by Phosphorylation Induced by Resistant Strains | Zendy

Fujio Kobayashi | Zendy; Masahito Yamaguchi | Zendy; Susumu Mitsuhashi | Zendy

Open Access

Activity of Lividomycin Against Pseudomonas aeruginosa: Its Inactivation by Phosphorylation Induced by Resistant Strains

Author(s) -

Fujio Kobayashi,

Masahito Yamaguchi,

Susumu Mitsuhashi

Publication year - 1972

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.1.1.17

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , in vitro , antibiotics , strain (injury) , pseudomonadaceae , pseudomonadales , minimum inhibitory concentration , enzyme , biology , bacteria , antibacterial agent , chemistry , biochemistry , genetics , anatomy

The antibacterial activity and enzymatic inactivation of lividomycin, a new aminoglycosidic antibiotic, were studied with 13 strains of Pseudomonas aeruginosa. The minimal inhibitory concentration of lividomycin was 12.5 to 25 mug/ml, and three strains were resistant to high concentrations of lividomycin (more than 200 mug/ml). It was found that P. aeruginosa TI-13 and K-11, highly lividomycin-resistant strains of clinical origin, strongly inactivated the drug. The third resistant strain, Km-41/R, was developed in vitro. Unlike the other resistant strains, Km-41/R, was developed in vitro. Unlike the other resistant strains, Km-41/R did not inactivate the drug, indicating that different mechanisms were involved in lividomycin resistance. By use of a cell-free extract from P. aeruginosa TI-13, the inactivation of lividomycin was found to be caused by the formation of a monophosphorylated product of the drug.

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