Stimulation of the Hexose Monophosphate Shunt in Human Neutrophils by Ascorbic Acid: Mechanism of Action | Zendy

Lawrence R. DeChatelet | Zendy; M. Robert Cooper | Zendy; Charles E. McCall | Zendy

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Stimulation of the Hexose Monophosphate Shunt in Human Neutrophils by Ascorbic Acid: Mechanism of Action

Author(s) -

Lawrence R. DeChatelet,

M. Robert Cooper,

Charles E. McCall

Publication year - 1972

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.1.1.12

Subject(s) - dehydroascorbic acid , pentose phosphate pathway , ascorbic acid , stimulation , biochemistry , hexose , myeloperoxidase , glutathione , chemistry , mechanism of action , vitamin c , metabolism , biology , glycolysis , enzyme , endocrinology , immunology , in vitro , food science , inflammation

The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H(2)O(2) and a bactericidal mechanism which is independent of myeloperoxidase.

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